In sepsis, mortality rises 7.6% per hour of delayed antibiotics. At Gini, the protocol is antibiotics within 60 minutes of ICU arrival — followed by aggressive fluid resuscitation and source control.
📍 Sector 69, SAS Nagar (Mohali), Punjab · Serving Chandigarh Tri-City
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Sepsis is the body's overwhelming response to an infection. The immune system, instead of fighting the infection locally, releases a flood of inflammatory mediators throughout the body. Blood vessels leak. Blood pressure falls. Organs — kidneys, liver, lungs, brain — start failing.
Untreated, sepsis progresses to septic shock (blood pressure unmaintained even with fluids) and multi-organ dysfunction. Mortality of septic shock is 30–50% even with optimal treatment — and rises rapidly with each hour of delay.
Sepsis is the leading cause of in-hospital deaths globally and the most preventable cause of death in any ICU.
For every hour antibiotics are delayed, mortality rises ~7.6%.
The first hour after sepsis recognition determines outcome more than any other intervention. The 1-hour bundle: blood cultures, broad-spectrum antibiotics, IV fluids 30 mL/kg, lactate measurement.
This is why ICU choice matters in suspected sepsis. A hospital that takes 3–4 hours to start antibiotics has worse mortality than a hospital that starts in 60 minutes — regardless of what happens after.
Suspect sepsis if a patient has a known or suspected infection PLUS any of:
In an elderly patient: confusion may be the only obvious sign. Don't dismiss new confusion as "just age."
0–60 minutes: Sepsis screen, blood cultures (before antibiotics), broad-spectrum IV antibiotics within 1 hour, aggressive crystalloid fluid resuscitation (30 mL/kg), lactate measurement.
1–6 hours: If hypotension persists despite fluids, vasopressors started (noradrenaline first line). Source control assessment — imaging, surgical opinion if abscess suspected. Ventilator support if respiratory failure develops.
6–24 hours: Antibiotic refinement based on culture results, ongoing organ support, glucose control critical for diabetics. Family communication.
Days 2–14: Source control consolidated. Step-down from ICU when stable. Average sepsis ICU stay: 7–14 days.
Sepsis without shock: ~80–90% survival with prompt treatment.
Septic shock: 50–70% survival depending on age, comorbidity, and source. Diabetics historically have ~10% lower survival than non-diabetics.
Gini's sepsis outcomes are tracked on an ongoing basis — the integration of endocrinology (Dr. Bhansali) into sepsis care for diabetics is one reason our outcomes hold up against larger centres.
For emergencies, call directly — every minute matters. For ICU enquiries or family member transfer, speak with our team.