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GLP-1 Therapy — Mounjaro, Ozempic, Wegovy (Primary Expertise)
GLP-1 receptor agonists have transformed diabetes and obesity medicine — but they are only as safe and effective as the clinical supervision behind them. Dr. Simranpreet has managed a large volume of patients on GLP-1 therapies, developing genuine expertise in drug selection, titration, side effect management, and long-term outcomes.
Her approach: complete pre-treatment metabolic workup (HbA1c, fasting insulin, HOMA-IR, kidney function, thyroid, lipids), individualised drug selection based on the patient's metabolic profile and goals, careful titration to maximise tolerability, and structured monthly monitoring.
She prescribes and manages: Mounjaro (tirzepatide) — for maximum weight loss and HbA1c reduction; Ozempic (semaglutide 1mg) — for diabetes with moderate weight loss; Wegovy (semaglutide 2.4mg) — for obesity without diabetes; Rybelsus (oral semaglutide) — for needle-averse patients or mild Type 2. She also evaluates emerging generic semaglutide options as they enter the Indian market.
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Medically Supervised Weight Loss
Weight loss is not just a lifestyle issue — for most patients, it is a medical and hormonal one. Insulin resistance, thyroid deficiency, cortisol dysregulation, PCOS, and hypothalamic dysfunction all make weight loss significantly harder than simple calorie restriction. Dr. Simranpreet investigates the hormonal and metabolic barriers to weight loss before designing a treatment plan.
Her weight loss programme: full metabolic assessment → identify root causes (insulin resistance, thyroid, cortisol, medications causing weight gain) → personalised intervention (GLP-1 therapy, dietary protocol, exercise prescription, medication review) → monthly monitoring with dose adjustment. She works with patients on realistic, sustainable outcomes — not crash programmes.
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Type 2 Diabetes Management
Type 2 diabetes is not a single condition — it exists on a spectrum from early insulin resistance to beta cell exhaustion, and effective management requires understanding where each patient sits on that spectrum. Dr. Simranpreet's endocrinology training gives her the depth to make these distinctions and tailor treatment accordingly.
She manages: newly diagnosed Type 2 diabetes, uncontrolled diabetes (HbA1c above 8%), patients on multiple medications without adequate control, insulin initiation and optimisation, switching between medication classes (metformin, SGLT2 inhibitors, DPP4 inhibitors, GLP-1 agonists, insulin), and managing diabetes alongside thyroid, PCOS, and other hormonal conditions.
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Thyroid Disorders
Thyroid disease is one of the most common endocrine conditions in India — and one of the most under-managed. Standard care often involves a single TSH test and a fixed dose of levothyroxine. Dr. Simranpreet's endocrinology training enables a more thorough approach: full panel testing (TSH, Free T3, Free T4, Anti-TPO, Anti-TG), identification of Hashimoto's thyroiditis as the underlying autoimmune cause, T3+T4 combination therapy for patients who remain symptomatic on T4 alone, and management of thyroid conditions in PCOS, pregnancy, and post-partum.
Conditions treated: hypothyroidism, hyperthyroidism, subclinical thyroid disease, Hashimoto's thyroiditis, Graves' disease, thyroid nodules (evaluation and monitoring), thyroid in pregnancy.
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PCOS & Hormonal Health
PCOS — now officially renamed PMOS (Polyendocrine Metabolic Ovarian Syndrome) — is fundamentally a metabolic and hormonal condition, not just a gynaecological one. Dr. Simranpreet's endocrinology background is particularly valuable here: she understands the insulin-androgen axis driving most PCOS, and treats the metabolic root rather than just managing symptoms.
Her PCOS protocol: full hormonal panel (AMH, LH, FSH, testosterone, DHEA-S, prolactin) + full metabolic panel (fasting insulin, HOMA-IR, HbA1c, lipid profile) + thyroid screen (co-existing in many PCOS patients). Treatment: metformin for insulin resistance, GLP-1 therapy in patients with obesity and significant insulin resistance, dietary intervention, cycle regulation, fertility planning in coordination with Dr. Deepika Gupta. She is particularly experienced in PCOS patients who haven't responded to standard pill-based treatment — because those patients have a metabolic problem that wasn't being treated.
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Insulin Resistance & Metabolic Syndrome
Insulin resistance is the common thread running through Type 2 diabetes, PCOS, fatty liver, abdominal obesity, and cardiovascular risk — yet most patients with significant insulin resistance have never been tested for it, because the test (fasting insulin + HOMA-IR) is rarely ordered.
Dr. Simranpreet systematically tests for insulin resistance and quantifies it using HOMA-IR. Her treatment approach addresses the root cause: dietary changes that specifically reduce insulin demand (low glycaemic index, high protein, time-restricted eating), resistance exercise prescription, metformin, GLP-1 therapy in appropriate candidates, and management of co-existing conditions that worsen insulin resistance (thyroid, sleep apnea, steroid use). She monitors treatment response with serial HOMA-IR and fasting insulin — not just glucose and HbA1c.
